METHODS OF DIAGNOSIS AND THERAPEUTIC TARGETING OF CLINICALLY INTRACTABLE MALIGNANT TUMORS

• Main Authors: GLINKSII, Guennadi, V, KELTNER, Llew
• Format: Patent
• Language: English; French
• Published: 23.11.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present disclosure is directed to methodologies or technologies for generating a predictor of a disease state (e.g. cancer-therapy efficacy status, cancer therapy progress, cancer prognosis, cancer diagnosis, therapy failure, relapse, recurrence, and the like) based on genomic and proteomic signatures, gene expression, and pathways & networks activation of endogenous human stem cell- associated retroviruses (SCAR). This disclosure is also directed to methods of targeting, designing, and using treatments for clinically intractable malignant tumors. La présente invention concerne des méthodologies ou des technologies permettant de générer un paramètre de prévision d'un état pathologique (par exemple, un état d'efficacité de thérapie anticancéreuse, le pronostic du cancer, le diagnostic du cancer, l'échec de la thérapie, la rechute, la récurrence et similaires) sur la base de signatures génomiques et protéomiques, de l'expression génique et de voies et réseaux d'activation de rétrovirus associés aux cellules souches humaines (SCAR) endogènes. L'invention concerne également des procédés de ciblage, de conception et d'utilisation de traitements pour des tumeurs malignes cliniquement réfractaires.