COMPOSITION FOR PROMOTING GROWTH OF STEM CELLS COMPRISING PHYTOSPHINGOSINE-1-PHOSPHATE OR DERIVATIVES THEREOF, AND COMPOSITION FOR CULTURING MEDIA OF STEM CELLS COMPRISING SAME

• Main Author: CHOI, Myeong Jun
• Format: Patent
• Language: English; French; Korean
• Published: 23.11.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present application relates to a composition for promoting the proliferation of adult stem cells further comprising phytosphingosine-1-phosphate (P1P), O-cyclic P1P (cP1P), N-acetylphytosphingosine-1-phosphate (NAPS-1-P), and pharmaceutically acceptable salts thereof in a basal medium, a composition for culturing adult stem cells comprising the same, or a composition for a culture medium of serum-free or low-serum adult stem cells. When the stem cells are cultured using the composition of the present application, the proliferation promotion, activity and differentiation potency of the stem cells can be improved, and the death of stem cells against external stress can be prevented. La présente demande concerne une composition visant à favoriser la prolifération de cellules souches adultes comprenant en outre de la phytosphingosine-1-phosphate (P1P), de la P1P O-cyclique (cP1P), de la N-acétylphytosphingosine-1-phosphate (NAPS-1-P), et des sels pharmaceutiquement acceptables de ceux-ci dans un milieu de base, une composition pour la culture de cellules souches adultes comprenant ceux-ci, ou une composition pour un milieu de culture de cellules souches adultes sans sérum ou à faible teneur en sérum. Lorsque les cellules souches sont cultivées à l'aide de la composition selon la présente invention, la promotion de la prolifération, l'activité et le potentiel de différenciation des cellules souches peuvent être améliorées, et la mort des cellules souches du fait du stress externe peut être prévenue. 본원은 기본배지에 추가로 P1P(피토스핑고신-1-포스페이트), cP1P(O-싸이클릭 P1P), NAPS-1-P(N-아세틸피토스핑고신-1-포스페이트), 및 이들의 약학적으로 허용가능한 염을 포함하는 성제 줄기세포 증식 촉진용 조성물, 이를 포함하는 성체 줄기세포 배양 조성물 또는 무혈청 또는 저혈청 성체 줄기세포 배양배지용 조성물에 관한 것으로, 본원의 조성물을 이용하여 줄기세포를 배양하면 줄기세포 증식 촉진, 활성 및 분화능이 개선되고 외부 스트레스에 대한 줄기세포 사멸을 방지할 수 있다.