A METHOD OF FILLING A CONTAINER WITH NO HEADSPACE

• Main Authors: JI, Wenchang, MANNING, Mark, BEGLEY, Patrick, OGEZ, John, LIU, Jun, PRADO, Isaias
• Format: Patent
• Language: English; French
• Published: 26.10.2017
• Subjects: BOTTLES, JARS OR SIMILAR CONTAINERS; CONVEYING; DISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISEPROVIDED FOR; HANDLING THIN OR FILAMENTARY MATERIAL; HUMAN NECESSITIES; HYGIENE; LIQUID HANDLING; MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGINGARTICLES OR MATERIALS; MEDICAL OR VETERINARY SCIENCE; OPENING, CLOSING; PACKING; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; STORING; TRANSPORTING; UNPACKING

The present invention is directed to methods for filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to methods for detecting headspace in a container. La présente invention concerne des procédés de remplissage d'un récipient, le récipient rempli ne disposant pas d'espace libre. La présente invention concerne en outre des procédés pour stabiliser une solution aqueuse de substance médicamenteuse en remplissant un récipient avec la solution aqueuse de substance médicamenteuse, le récipient rempli n'ayant pas d'espace libre. La présente invention concerne en outre des procédés pour détecter l'espace libre dans un récipient.