SOLUBLE C5aR ANTAGONISTS

Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutic...

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Main Authors PUNNA, Sreenivas, SONG, Yang, KRASINSKI, Antoni, MALI, Venkat, Reddy, ZHANG, Penglie, STELLA, Valentino, J, ZENG, Yibin, FAN, Pingchen, MIAO, Shichang
Format Patent
LanguageEnglish
French
Published 12.10.2017
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. L'invention concerne des composés pour moduler le récepteur C5a. Lesdits composés présentent la formule suivante (I) comprenant des stéréoisomères et des sels pharmaceutiquement acceptables, R1, R2 et R3 étant tels que définis dans la description. L'invention concerne également, d'une part des procédés associés à l'élaboration et à l'utilisation de tels composés, et d'autre part des compositions pharmaceutiques comprenant de tels composés.
Bibliography:Application Number: WO2017US25704