DIFFERENTIATION-PROMOTED PLURIPOTENT STEM CELL AND USE THEREOF

• Main Authors: MATSUMOTO Takuya, KISA Fumihiko, OKANO Hideyuki, FUJIMORI Koki, KUZUMAKI Naoko, AKAMATSU Wado
• Format: Patent
• Language: English; French; Japanese
• Published: 05.10.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

A culture medium for inducing a differentiation-promoted pluripotent stem cell from a pluripotent stem cell, said culture medium containing a glycogen synthase kinase 3β (GSK3β) inhibitor, a bone morphogenic protein (BMP) signal inhibitor and a transforming growth factor (TGF)-β inhibitor as active ingredients. L'invention concerne un milieu de culture pour induire une cellule souche pluripotente stimulée par différenciation à partir d'une cellule souche pluripotente, ledit milieu de culture contenant un inhibiteur de glycogène synthase kinase 3β (GSK3β), un inhibiteur de signal de protéine morphogénique osseuse (BMP) et un inhibiteur du facteur de croissance transformant (TGF)-β en tant que principes actifs. Ｇｌｙｃｏｇｅｎ　ｓｙｎｔｈａｓｅ　ｋｉｎａｓｅ　３β（ＧＳＫ３β）阻害剤、Ｂｏｎｅ　ｍｏｒｐｈｏｇｅｎｉｃ　ｐｒｏｔｅｉｎ　（ＢＭＰ）シグナル阻害剤及びＴｒａｎｓｆｏｒｍｉｎｇ　ｇｒｏｗｔｈ　ｆａｃｔｏｒ（ＴＧＦ）－β阻害剤を有効成分として含有する、多能性幹細胞の分化促進型多能性幹細胞への誘導用培地。