CARBOXAMIDE DERIVATIVES USEFUL AS RSK INHIBITORS

Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity. Such carboxamide derivatives form...

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Bibliographic Details
Main Authors NAGIREDDY, Jaipal, Reddy, VAN DRIE, John, H, DAYNARD, Timothy, S, DUNN, Sandra, E, ANNEDI, Subhash, JAYANTHAN, Aarthi, HUYNH, My-my
Format Patent
LanguageEnglish
French
Published 24.08.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are carboxamide derivatives that are useful as inhibitors of p90 ribosomal S6 kinase (RSK), pharmaceutical compositions comprising the derivatives, and methods of using the derivatives in treating diseases or conditions associated with RSK activity. Such carboxamide derivatives form bicyclic and tricyclic ring systems and the disease or condition associated with RSK activity in a mammal is cancer. L'invention concerne des dérivés de carboxamide qui sont utiles en tant qu'inhibiteurs de la kinase S6 ribosomale p90 (RSK), des compositions pharmaceutiques comprenant les dérivés, et des procédés d'utilisation des dérivés dans le traitement de maladies ou d'affections associées à l'activité de RSK.
Bibliography:Application Number: WO2017IB00237