PORTABLE UREA SENSOR MODULE USING INSOLUBLE UREASE IMMOBILIZATION POROUS SUPPORT

• Main Authors: SUNG, Gun Yong, LEE, Jung Eun, MOON, Bo Mi, PARK, Chan Hum
• Format: Patent
• Language: English; French; Korean
• Published: 27.07.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a structure of a compact urea sensor module, in which an insoluble urease immobilization porous support, formed by immobilizing a urease on a porous structure made of a natural polymer, such as silkfibroin, or a synthetic polymer, is mounted within a fluid chamber, and an electrode surface of a three-electrode strip is exposed from the bottom surface of the chamber. The urea sensor according to the present invention is a sensor essential for evaluating a regenerated liquid of a portable peritoneal fluid regeneration system and has advantages in terms of portability, reproducibility, mass productivity, convenience and so on. Thus, the present invention could significantly contribute to the disease management of patients suffering from chronic kidney disease. La présente invention concerne une structure d'un module capteur d'urée compact, dans lequel un support poreux d'immobilisation d'uréase insoluble, formé par l'immobilisation d'une uréase sur une structure poreuse constituée d'un polymère naturel, comme la fibroïne de soie, ou d'un polymère synthétique, est monté à l'intérieur d'une chambre de fluide, et une surface d'électrode d'une bande de trois électrodes est exposée depuis la surface inférieure de la chambre. Le capteur d'urée selon la présente invention est un capteur essentiel pour évaluer un liquide régénéré d'un système de régénération de fluide péritonéal portatif et présente des avantages en termes de portabilité, reproductibilité, productivité de masse, commodité et ainsi de suite. Ainsi, la présente invention pourrait contribuer de manière significative à la prise en charge de maladie chez des patients souffrant d'une maladie rénale chronique. 본 발명은 실크 피브로인 등과 같은 천연고분자나 합성 고분자를 소재로 제작된 다공성 구조체에 요소분해효소를 고정화한 요소분해효소 고정화 불용성 다공성 지지체를 유체 챔버 내에 장착하고 챔버 바닥면에 3전극 스트립의 전극면이 노출된 소형 요소 센서 모듈의 구조에 관한 것이다. 본 발명에 따른 요소 센서는 휴대형 복막투석액 재생 시스템의 재생액의 평가를 위해 필수적인 센서일 뿐 아니라, 휴대성, 재현성, 대량 생산성, 간편성 등의 장점이 있어, 만성 신장질환 환자들의 질환 관리에 크게 기여할 것이다.