BINDING MEMBERS WITH ALTERED DIVERSITY SCAFFOLD DOMAINS

This invention relates to libraries of binding members that each comprise a fusion protein which contains a donor diversity scaffold domain, such as a cysteine rich protein,inserted within a recipient diversity scaffold domain,such as an antibody constant or variable domain. Libraries and methods of...

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Bibliographic Details
Main Authors SURADE, Sachin, LUETKENS, Tim, DYSON, Michael, KARATT VELLATT, Aneesh, MCCAFFERTY, John, MASTERS, Edward
Format Patent
LanguageEnglish
French
Published 13.07.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:This invention relates to libraries of binding members that each comprise a fusion protein which contains a donor diversity scaffold domain, such as a cysteine rich protein,inserted within a recipient diversity scaffold domain,such as an antibody constant or variable domain. Libraries and methods of generating libraries are provided, along with screening methods, binding members and methods of using the binding members. L'invention concerne des bibliothèques d'éléments de liaison qui comprennent chacun une protéine hybride qui contient un domaine d'échafaudage à donneur flexible, par exemple une protéine riche en cystéine, inséré dans un domaine d'échafaudage à receveur flexible, par exemple un domaine variable ou constant d'anticorps. L'invention concerne également des bibliothèques et des procédés permettant de générer des bibliothèques, ainsi que des procédés de criblage, des éléments de liaison et des procédés d'utilisation des éléments de liaison.
Bibliography:Application Number: WO2017EP50337