USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION

• Main Authors: JUNG, Joon, CARLSON, Kenneth E, CURRIE, Mark G
• Format: Patent
• Language: English; French
• Published: 19.10.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to methods, uses, pharmaceutical compositions and kits comprising an sGC stimulator or a pharmaceutically acceptable salt thereof, alone or in combination with one or more additional therapeutic agents, for the treatment of a gastrointestinal sphincter disorder. Gastrointestinal sphincter disorders include, but are not limited to, an achalasia of a sphincter of the gastrointestinal tract, a spastic sphincter of the gastrointestinal tract or sphincter spasms, or a hypertensive sphincter of the gastrointestinal tract. La présente invention concerne des procédés, utilisations, compositions pharmaceutiques et kits comprenant un stimulateur de la sGC ou un sel pharmaceutiquement acceptable de celui-ci, seul ou en combinaison avec un ou plusieurs agents thérapeutiques supplémentaires, pour le traitement d'un trouble du sphincter gastro-intestinal. Les troubles du sphincter gastro-intestinal comprennent, mais sans s'y limiter, une achalasie d'un sphincter du tractus gastro-intestinal, un sphincter spastique du tractus gastro-intestinal ou des spasmes du sphincter, ou un sphincter hypertendu du tractus gastro-intestinal.