DOTA SYNTHESIS

The present invention provides methods for the preparation of compounds useful in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4, 7,10- tetraacetic acid (DOTA) and also methods for the prepa...

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Main Authors HUSSAIN, Khalid, MEIJER, Andreas, Richard, NILSEN, Sondre, GAUSEMEL, Ingvil, THANING, Mikkel, jAC, AABYE, Arne, Wang, HAUGAN, Jarle, Andre, ENES, Nikolai, SUMIHAR, Silalahi
Format Patent
LanguageEnglish
French
Published 22.06.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides methods for the preparation of compounds useful in vivo therapeutic and diagnostic applications. In particular, the present invention provides a method for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4, 7,10- tetraacetic acid (DOTA) and also methods for the preparation of metal chelates of DOTA. La présente invention concerne des procédés de préparation de composés utiles dans des applications thérapeutiques et diagnostiques in vivo. En particulier, la présente invention concerne un procédé de synthèse d'acide 1,4,7,10-tétraazacyclododécane-1,4,7,10-tétraacétique (DOTA), ainsi que des procédés pour la préparation de chélates métalliques du DOTA.
Bibliography:Application Number: WO2016EP81705