N-[(AMINOSULFONYL)PHENYL]-2-(1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE)-HYDRAZINECARBOTHIOAMIDE DERIVATIVES FOR TREATING CANCER AND IMMUNOLOGICAL DISORDERS

• Main Authors: KARALI, Nilgun, GOKTAS, Fusun, USTUNDAG, Gokce Cihan, ERASLAN, Pinar
• Format: Patent
• Language: English; French
• Published: 15.06.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

N-[(aminosulfonyl)phenyl]-2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-hydrazinecarbothioamide derivatives of the following formula (III) for treating cancer and immunological disorders. R5, R6 and R7 are each independently selected from hydrogen and a sulfonamide group, provided that at least one of R5, R6 or R7 is a sulfonamide group. The substituents R1 to R4 are each independently either hydrogen or one of the substituents defined in the claims. La présente invention concerne des dérivés de N-[(aminosulfonyl)phényl]-2-(1,2-dihydro-2-oxo-3H-indol-3-ylidène)-hydrazinecarbothioamide de la formule (III) suivante pour le traitement du cancer et de troubles immunologiques. R5, R6 et R7 sont chacun indépendamment choisis parmi hydrogène et un groupe sulfonamide, à condition qu'au moins l'un de R5, R6 ou R7 soit un groupe sulfonamide. Les substituants R1 à R4 sont chacun indépendamment hydrogène ou un des substituants définis dans les revendications.