MODULATORS OF ROR-GAMMA

Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and m...

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Main Authors XU, Zhenrong, CLAREMON, David, A, ZHUANG, Linghang, TICE, Colin, M, JIA, Lanqi, DILLARD, Lawrence, Wayne, FAN, Yi, SINGH, Suresh, B, YUAN, Jing
Format Patent
LanguageEnglish
French
Published 26.05.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided are novel compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by RORy. Also provided are pharmaceutical compositions comprising the novel compounds of Formula I and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders. L'invention concerne de nouveaux composés de formule I : des sels pharmaceutiquement acceptables de ceux-ci, et des compositions pharmaceutiques de ceux-ci, qui sont utiles dans le traitement de maladies et de troubles médiés par RORγ. L'invention concerne également des compositions pharmaceutiques comprenant les nouveaux composés de formule I et des procédés pour les utiliser dans le traitement d'un ou de plusieurs troubles ou maladies inflammatoires, métaboliques, auto-immun(e)s et autres.
Bibliography:Application Number: WO2016US62422