HETERO-SUBSTITUTED CYCLIC LACTONE ANALOGUES AND USES THEREOF

The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells. La présente invention concerne SL et des dérivés...

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Main Authors MARTINEZ, Mariano, GAUDIO, Flavio G, ORDONEZ, Paola E, GUZMAN, Monica L, BALICK, Michael J, COMPADRE, Cesar M, JONES, Darin E
Format Patent
LanguageEnglish
French
Published 11.05.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells. La présente invention concerne SL et des dérivés de SL comprenant un substituant polaire adjacent à l'anneau de lactone. De plus, la présente invention concerne des procédés d'utilisation de SL et des dérivés de SL afin d'inhiber la croissance de cellules cancéreuses leucémiques.
Bibliography:Application Number: WO2016US60318