ASSAYS FOR MASSIVELY COMBINATORIAL PERTURBATION PROFILING AND CELLULAR CIRCUIT RECONSTRUCTION

The present invention provides tools and methods for the systematic analysis of genetic interactions, including higher order interactions. The present invention provides tools and methods for combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pat...

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Bibliographic Details
Main Authors ADAMSON, Brittany, NORMAN, Thomas, LANDER, Eric, S, CONG, Le, ROZENBLATT-ROSEN, Orit, REGEV, Aviv, CLEARY, Brian, GAUBLOMME, Jellert, SHALEK, Alexander, K, WEISSMAN, Jonathan, DIXIT, Atray, PAMAS, Oren
Format Patent
LanguageEnglish
French
Published 04.05.2017
Subjects
CALCULATING
COMPUTING
COUNTING
ELECTRIC DIGITAL DATA PROCESSING
PHYSICS
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Summary:The present invention provides tools and methods for the systematic analysis of genetic interactions, including higher order interactions. The present invention provides tools and methods for combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development. La présente invention concerne des outils et des procédés pour l'analyse systématique d'interactions génétiques, y compris les interactions d'ordre supérieur. La présente invention concerne des outils et des procédés pour effectuer la vérification combinatoire de circuits cellulaires, pour examiner des circuits cellulaires, pour délimiter des voies moléculaires, et/ou pour identifier des cibles appropriées au développement de produits thérapeutiques.
Bibliography:Application Number: WO2016US59233