FACTOR XIa INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibi...

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Main Authors ALI, Amjad, ZHU, Cheng, NEELAMKAVIL, Santhosh, F, GAO, Ying-Duo, SUN, Wanying, BARA, Thomas, YANG, Meng, SHEN, Dong-Ming, XU, Jiayi, ZHOU, Wei, HARPER, Bart, LIM, Yeon-Hee, LIU, Weiguo, EDMONDSON, Scott, D, MERTZ, Eric
Format Patent
LanguageEnglish
French
Published 04.05.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein. La présente invention concerne un composé de formule (I) et des compositions pharmaceutiques comprenant un ou plusieurs desdits composés, ainsi que des méthodes d'utilisation desdits composés pour traiter ou prévenir les thromboses, les embolies, l'hypercoagulabilité ou les modifications fibrotiques. Lesdits composés sont des inhibiteurs sélectifs du facteur XIa ou des inhibiteurs doubles du facteur XIa et de kallicréine plasmatique.
Bibliography:Application Number: WO2016US58362