5-NITROINDAZOLE DERIVATIVES AND USE THEREOF AS ANTIPROTOZOAL AGENTS

• Main Authors: IBÁÑEZ ESCRIBANO, Alejandra, CUMELLA MONTÁNCHEZ, José María, REVIRIEGO PICÓN, Felipe, NOGAL RUÍZ, Juan José, ESCARIO GARCÍA-TREVIJANO, José Antonio, FONSECA BERZAL, Cristina Rosa, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC) (33,3%), GÓMEZ BARRIO, Alicia, ARÁN REDÓ, Vicente Jesús
• Format: Patent
• Language: English; French; Spanish
• Published: 04.05.2017
• Subjects: CHEMISTRY; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention relates to two families of 5-nitroindazole derivatives that have antiparasitic properties and to the use thereof for the production of a drug, preferably for the treatment of infections caused by pathogenic protozoa from the Trypanosomatidae and Trichomonadidae families, such as Chagas disease, leishmaniasis and trichomoniasis. La presente invención se refiere a dos familias de derivados de 5-nitromdazol que poseen propiedades antiparasitarias y a su empleo para la fabricación de un medicamento, preferentemente para el tratamiento de infecciones causadas por protozoos patógenos de las familias Trypanosomatidae y Trichomonadidae, tales como la enfermedad de Chagas, la leishnianiosis y la tricomonosis. La présente invention concerne deux familles de dérivés de 5-nitroindazole qui possèdent des propriétés antiparasitaires et leur utilisation dans la fabrication d'un médicament, de préférence pour le traitement des infections causées par des protozoaires pathogènes des familles Trypanosomatidae et Trichomonadidae, telles que la maladie de Chagas, la leishmaniose et la trichomonose.