ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION HAVING ANTICANCER ACTIVITY

• Main Authors: MILLER, Duncan Charles, WATSON, David Wyn, MITCHELL, Dale Robert, JOHNSON, Christopher Norbert, PEACH, Joanne, ST. DENIS, Jeffrey David, CANO, Celine Florence, WHITTAKER, Benjamin Paul, HOLVEY, Rhian Sara, CULLY, Sarah, LEWIS, Arwel, CONS, Benjamin David, BUCK, Ildiko Maria, TAMANINI, Emiliano, HARDCASTLE, Ian Robert, OSBORNE, James Daniel, HOWARD, Steven, GOLDING, Bernard Thomas, HIRST, Kim Louise, REES, David Charles, NOBLE, Martin Edward Mäntylä, CHESSARI, Gianni, GRIFFIN, Roger John
• Format: Patent
• Language: English; French
• Published: 06.04.2017
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a compound of formula (I): (I) or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds. L'invention concerne un composé de formule (I) : (I) ou un tautomère ou un solvate ou un sel pharmaceutiquement acceptable de celui-ci, les divers substituants étant tels que définis dans les revendications. L'invention concerne également des compositions pharmaceutiques contenant les composés de formule (I), des procédés de fabrication des composés et les utilisations médicales des composés.