LIGHT-CONTROLLED GENE DELIVERY WITH VIRUS VECTORS THROUGH INCORPORATION OF OPTOGENETIC PROTEINS AND GENETIC INSERTION OF NON-CONFORMATIONALLY CONSTRAINED PEPTIDES

This invention describes light-controlled delivery to the nucleus of target cells via viral vectors modified using optogenetic tools. This invention also describes tools for the display of proteins on the surface of adeno-associated virus using enzymatic tools to display the proteins in a more favor...

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Bibliographic Details
Main Authors JUDD, Justin, TABOR, Jeffrey, GOMEZ, Eric, GERHARDT, Karl, HO, Michelle, SUH, Junghae
Format Patent
LanguageEnglish
French
Published 08.06.2017
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:This invention describes light-controlled delivery to the nucleus of target cells via viral vectors modified using optogenetic tools. This invention also describes tools for the display of proteins on the surface of adeno-associated virus using enzymatic tools to display the proteins in a more favorable thermodynamic configuration to enhance activity of the proteins or their targets.. La présente invention concerne l'insertion régulée par la lumière dans le noyau de cellules cibles par l'intermédiaire de vecteurs viraux modifiés à l'aide d'outils optogénétiques. L'invention concerne également des outils pour l'exposition de protéines sur la surface de virus adéno-associés au moyen d'outils enzymatiques pour exposer les protéines dans une configuration thermodynamique plus favorable pour améliorer l'activité des protéines ou de leurs cibles.
Bibliography:Application Number: WO2016US53200