METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS

Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula (I): wherein the 1' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the...

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Bibliographic Details
Main Authors FENG, Joy Yang, RAY, Adrian S, JORDAN, Robert, MACKMAN, Richard L, SIEGEL, Dustin, CLARKE, Michael O' Neil Hanrahan
Format Patent
LanguageEnglish
French
Published 23.03.2017
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula (I): wherein the 1' position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections. L'invention concerne des procédés permettant de traiter des infections virales à Arenaviridae et Coronaviridae par l'administration de nucléosides et de promédicaments à base de ceux-ci, représentés par la formule (I), la position 1' du sucre du nucléoside étant substituée. Les composés, les compositions et les procédés selon l'invention sont particulièrement utiles pour le traitement d'infections par le virus Lassa et le virus Junin.
Bibliography:Application Number: WO2016US52092