COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, CONTAINING, AS ACTIVE INGREDIENT, STEM CELLS OVEREXPRESSING SOD3

• Main Authors: KANG, Kyung Sun, KIM, Tae Yoon
• Format: Patent
• Language: English; French; Korean
• Published: 23.03.2017
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present invention provides a pharmaceutical composition for preventing or treating inflammatory diseases, containing, as an active ingredient, stem cells overexpressing SOD3. The present inventor has ascertained that mesenchymal stem cells (MSCs) overexpressing SOD3 have a stronger antioxidant activity and immune regulatory function than normal MSCs, and thus the MSCs overexpressing SOD3 can be an effective treatment agent for inflammatory diseases, autoimmune diseases, organ transplant rejection and the like. La présente invention concerne une composition pharmaceutique pour la prévention ou le traitement de maladies inflammatoires, contenant, en tant que principe actif, des cellules souches surexprimant SOD3. L'auteur de la présente invention a établi que des cellules souches mésenchymateuses (MSC) surexprimant SOD3 ont une plus forte activité antioxydante et une fonction de régulation immunitaire que les cellules souches mésenchymateuses normales, et, par conséquent, les cellules souches mésenchymateuses surexprimant SOD3 peuvent être un agent de traitement efficace pour des maladies inflammatoires, des maladies auto-immunes, le rejet de greffe d'organe et analogues. 본 발명은 SOD3를 과발현하는 줄기세포를 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 약학적 조성물을 제공한다. 본 발명자는 SOD3를 과발현하는 중간엽 줄기세포 (MSC)가 일반 MSC에 비해 더욱 강한 항산화 활성, 면역조절기능을 가진다는 것을 확인하였으며, 따라서, SOD3를 과발현하는 MSC는 염증성 질환이나 자가면역질환, 장기이식 거부반응 등에 대하여 효과적인 치료제가 될 수 있다.