ION-ACTIVATED PHOTOLABILE COMPOUNDS

• Main Authors: HECKMAN, Laurel, M, LAVIS, Luke, D, SCHREITER, Eric, R, GRIMM, Jonathan, B
• Format: Patent
• Language: English; French
• Published: 09.03.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; ELECTROTHERAPY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MAGNETOTHERAPY; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; RADIATION THERAPY; TESTING; ULTRASOUND THERAPY

The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein Z includes a maskable molecule; L is selected from a bond, C, C(O), O, alkyl, (O)alkyl, and alkoxy; R1 is selected from H, halogen, alkyl, and acyl; each R2 is independently selected from H, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from COOH and COO(alkyl); and R3 is selected from H, alkyl, aryl, halogen, CN, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, CHO, COOH, COO(alkyl), COO(aryl), PO3H2, and SO3H, and is optionally substituted with one or more heteroatoms independently selected from N, O, and S, halogen, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, NO2, CHO, COO, COOH, COO(alkyl), COO(aryl), C(O)NR2, PO3H2, and/or SO3H. Also provided are methods of detecting calcium and treating a subject with the analyte-activated photolabile compounds. La présente invention concerne des composés photolabiles activés par analytes. Les composés comprennent la formule : Z comprend une molécule pouvant être masquée; L est choisi parmi une liaison, C, C(O), O, alkyle, (O)alkyle et alcoxy; R1 est choisi parmi H, halogène, alkyle et acyle; chaque R2 est choisi indépendamment parmi H, alkyle, aryle et acyle, et est éventuellement substitué par un ou plusieurs hétéro-atomes choisis indépendamment parmi COOH et COO(alkyle); et R3 est choisi parmi H, alkyle, aryle, halogène, CN, OH, O(alkyle), O(aryle), SH, S(alkyle), S(aryle), amine, CHO, COOH, COO(alkyle), COO(aryle), PO3H2 et SO3H, et est éventuellement substitué par un ou plusieurs hétéro-atomes choisis indépendamment parmi N, O, et S, halogène, OH, O(alkyle), O(aryle), SH, S(alkyle), S(aryle), amine, NO2, CHO, COO, COOH, COO(alkyle), COO(aryle), C(O)NR2, PO3H2 et/ou SO3H. L'invention concerne également des procédés de détection de calcium et de traitement d'un sujet avec les composés photolabiles activés par analytes.