ENHANCING MICROALGAL METABOLISM OF XYLOSE

• Main Authors: BENJAMIN, Jeremy, WOODHALL, David, MUISE, Denise, MERKX-JACQUES, Alexandra, SCAIFE, Mark, RASMUSSEN, Holly, ARMENTA, Roberto E
• Format: Patent
• Language: English; French
• Published: 19.01.2017
• Subjects: ANIMAL AND VEGETABLE OILS, FATS, FATTY SUBSTANCES AND WAXES; BEER; BIOCHEMISTRY; CANDLES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; DETERGENTS; ENZYMOLOGY; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS,OILS, OR FATTY ACIDS OBTAINED THEREFROM; FATTY ACIDS FROM FATS, OILS OR WAXES; FATTY ACIDS THEREFROM; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided herein are recombinant microorganisms having two or more copies of a nucleic acid sequence encoding xylose isomerase, wherein the nucleic acid encoding the xylose isomerase is an exogenous nucleic acid. Optionally, the recombinant microorganisms include at least one nucleic acid sequence encoding a xylulose kinase and/or at least one nucleic acid sequence encoding a xylose transporter. The provided recombinant microorganisms are capable of growing on xylose as a carbon source. L'invention concerne des micro-organismes de recombinaison comprenant deux copies ou plus d'une séquence d'acide nucléique codant pour la xylose isomérase, l'acide nucléique codant pour la xylose isomérase étant un acide nucléique exogène. Les micro-organismes de recombinaison comprennent éventuellement au moins une séquence d'acide nucléique codant pour une xylulose kinase et/ou au moins une séquence d'acide nucléique codant pour un transporteur de xylose. L'invention concerne des micro-organismes de recombinaison capables de croître sur de la xylose comme source de carbone.