INHIBITORS OF PROTOTYPIC GALECTIN DIMERIZATION AND USES THEREOF

• Main Authors: DOUCET, Nicolas, ST-PIERRE, Yves, VLADOIU, Maria-Claudia, CHATENET, David
• Format: Patent
• Language: English; French
• Published: 01.12.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

Agents that inhibit the dimerization of a prototypic galectin such as galectin-7 are described. These agents, for example antibodies and peptides, bind to a domain corresponding to residues 13-25, 86-108 and/or 129-135 of human galectin-7. The use of such agents to inhibit a biological, physiological and/or pathological process that involves prototypic galectin dimerization, for example for the inhibition of galectin-7-mediated apoptosis and the treatment of galectin-7-expressing cancers, is also described. L'invention concerne des agents qui inhibent la dimérisation de galectines prototypiques telle que la galectine-7. Ces agents, par exemple des anticorps et des peptides, se lient à un domaine correspondant aux résidus 13-25, 86-108 et/ou 129-135 de la galectine-7. L'invention concerne également l'utilisation de tels agents pour inhiber un processus biologique, physiologique et/ou pathologique impliquant la dimérisation de galectines prototypiques, par exemple pour inhiber l'apoptose médiée par la galectine-7 et traiter les cancers exprimant la galectine-7.