A METHOD OF CHIRAL RESOLUTION OF THE KEY INTERMEDIATE OF THE SYNTHESIS OF APREMILAST AND ITS USE FOR THE PREPARATION OF PURE APREMILAST

The present invention provides a method of chiral resolution of racemic amines of the benzyl type by means of salts formed with tartaric acid of formula (3) and intermediate of formula (2), and their use in the synthesis of Apremilast of formula 1. La présente invention concerne un procédé de résolu...

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Bibliographic Details
Main Authors KLVANA, Robert, FAIGL, Ferenc, DOUBSKY, Jan, MIZSAK, Agnes, FOGASSY, Elemer, RICHTER, Jindrich, MATRAVOLGYI, Bela
Format Patent
LanguageEnglish
French
Published 13.10.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention provides a method of chiral resolution of racemic amines of the benzyl type by means of salts formed with tartaric acid of formula (3) and intermediate of formula (2), and their use in the synthesis of Apremilast of formula 1. La présente invention concerne un procédé de résolution chirale d'amines racémiques du type benzyle au moyen de sels formés avec de l'acide tartrique de formule (3) et d'intermédiaire de formule (2), et leur utilisation dans la synthèse d'aprémilast de formule 1.
Bibliography:Application Number: WO2016CZ00038