BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY

The compounds of formula I, wherein the variables are as defined herein, and pharmaceutically acceptable salts thereof are useful as inhibitors of the PAR-2 signaling pathway. The compounds of formula I and pharmaceutically acceptable compositions comprising such compounds can be employed for treati...

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Main Authors SAYEGH, Camil Elie, MARTEL, Julien, FOURNIER, Pierre-Andre, LACOSTE, Jean-Eric, VALLEE, Frederic, DIETRICH, Evelyne, STURINO, Claudio
Format Patent
LanguageEnglish
French
Published 29.09.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The compounds of formula I, wherein the variables are as defined herein, and pharmaceutically acceptable salts thereof are useful as inhibitors of the PAR-2 signaling pathway. The compounds of formula I and pharmaceutically acceptable compositions comprising such compounds can be employed for treating various diseases, disorders, and conditions. L'invention concerne des composés de formule (I) dans laquelle les variables sont telles que définies dans la description, et des sels pharmaceutiquement acceptables de ceux-ci, qui sont utiles en tant qu'inhibiteurs de la voie de signalisation PAR-2. Lesdits composés de formule (I) et des compositions pharmaceutiquement acceptables comprenant de tels composés peuvent être utilisés pour le traitement de diverses maladies, et de divers troubles et états.
Bibliography:Application Number: WO2016US23324