PHARMACEUTICAL COMPOSITION FOR INHIBITING GROWTH OF CANCER STEM CELLS, CONTAINING ALDEHYDE INHIBITOR AND BIGUANIDE-BASED COMPOUND

• Main Authors: JO, YUN HEE, KIM, SOO YOUL, KIM, EUI HYUN, KANG, SEOK GU, LEE, JI HYUN, PARK, JUNSEONG, SHIM, JIN KYOUNG, CHANG, JONG HEE
• Format: Patent
• Language: English; French; Korean
• Published: 11.08.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition for inhibiting the growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical composition according to the present invention uses an aldehyde inhibitor together with a biguanide-based compound so as to effectively inhibit the growth of cancer stem cells, such as neurospheres, and inhibits the proliferation, infiltration, and metastasis of cancer cells, thereby enabling the prevention and/or treatment of cancer such as brain cancer. La présente invention concerne une composition pharmaceutique permettant d'inhiber la croissance de cellules souches du cancer, contenant un inhibiteur de l'aldéhyde et un composé à base de biguanide. La composition pharmaceutique selon la présente invention utilise un inhibiteur de l'aldéhyde conjointement à un composé à base de biguanide de manière à inhiber efficacement la croissance de cellules souches cancéreuses, telles que des neurosphères, et inhibe la prolifération, l'infiltration et la métastase de cellules cancéreuses, ce qui permet la prévention et/ou le traitement du cancer, tel que le cancer du cerveau. 본 발명은 알데히드 억제제 및 비구아나이드 계열 화합물을 포함하는 암 줄기세포의 성장 억제용 약학적 조성물에 관한 것이다. 본 발명에 따른 약학적 조성물은 알데히드 억제제와 비구아나이드 계열 화합물을 함께 사용하여, 신경구 등의 암 줄기세포의 성장을 효과적으로 저해하고, 암 세포의 증식, 침윤 및 전이 또한 억제하여 뇌암 등의 암을 예방 및/또는 치료할 수 있다.