IgG BISPECIFIC ANTIBODIES AND PROCESSES FOR PREPARATION

The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/ CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same. La présente inv...

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Main Authors ALDAZ, HECTOR, ATWELL, SHANE, KUHLMAN, BRIAN ARTHUR, FRONING, KAREN J, DEMAREST, STEPHEN J, LEAVER-FAY, ANDREW PHILIP
Format Patent
LanguageEnglish
French
Published 28.07.2016
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/ CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same. La présente invention concerne des anticorps IgG complètement bispécifiques comprenant des résidus conçus dans l'interface des domaines chaîne lourde-chaîne lourde (CH3/ CH3), des procédés de préparation desdits anticorps IgG complètement bispécifiques, et des acides nucléiques, des vecteurs et des cellules hôtes codant ceux-ci.
Bibliography:Application Number: WO2016US14313