FACTOR XIA INHIBITORS

The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibi...

Full description

Saved in:
Bibliographic Details
Main Authors ALI, AMJAD, MONINGKA, REMOND, HRUZA, ALAN, SUN, WANYING, LIU, WEIGUO, EDMONDSON, SCOTT, D, BROCKUNIER, LINDA, L, SO, SUNG-SAU, NEELAMKAVIL, SANTHOSH, F, MERTZ, ERIC, GAO, YING-DUO
Format Patent
LanguageEnglish
French
Published 28.07.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein. La présente invention concerne un composé de formule (I) et des compositions pharmaceutiques comprenant un ou plusieurs desdits composés, ainsi que des méthodes d'utilisation desdits composés pour traiter ou prévenir les thromboses, les embolies, l'hypercoagulabilité ou les modifications fibreuses. Ces composés sont des inhibiteurs sélectifs du facteur XIa ou des inhibiteurs doubles du facteur XIa et de la kallicréine plasmatique.
Bibliography:Application Number: WO2016US13507