DOSAGE REGIMEN FOR MADCAM ANTAGONISTS

• Main Authors: HASSAN-ZAHRAEE, Mina, ZHANG, Weidong, TILLEY, Mera Krishnan, PRADHAN, Vivekananda, COMER, Gail M, VINCENT, Michael Steven, BANERJEE, Anindita, CATALDI, Fabio, PAGE, Karen Michelle, AHMAD, Alaa, CLARE, Robert A, VON SCHACK, David J
• Format: Patent
• Language: English; French
• Published: 20.10.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a method for the treatment of a patient comprising administering to the patient an initial dose of between about 1 mg and about 150 mg of a MAdCAM antagonist antibody. Biomarkers for assessing a patient's response to anti-MAdCAM treatment are also provided. La présente invention concerne une méthode pour le traitement d'un patient comprenant l'administration au patient d'une dose initiale comprise entre environ 1 mg et environ 150 mg d'un anticorps antagoniste de MAdCAM. L'invention concerne également des biomarqueurs pour évaluer la réponse d'un patient au traitement anti-MAdCAM.