COMPOSITION CONTAINING PORIA COCOS BARK EXTRACT FOR PREVENTING, IMPROVING OR TREATING NEURODEGENERATIVE DISORDERS

• Main Authors: KIM, Eun Jin, RYU, Ja Young, CHOI, Song Hyen, KIM, So Young, CHO, Young Woong, GO, Hyo Sang, JEONG, Jin Seok, SOHN, Mi Won, CHOI, Sang Zin
• Format: Patent
• Language: English; French; Korean
• Published: 29.06.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a pharmaceutical composition containing a Poria cocos bark extract as an effective ingredient for preventing or treating neurodegenerative disorders, and to a food composition for preventing or improving neurodegenerative disorders. The Poria cocos bark extract contained as an effective ingredient in the composition of the present invention has a function of protecting neurons by generation of beta-amyloid, inhibition of tau phosphorylation, and promotion of NFG generation, and a function of improving memory by protection of neurons and inhibition of acetylcholinesterase, and thus can be usefully used in a pharmaceutical composition for preventing or treating neurodegenerative disorders or a functional food for said purpose. La présente invention concerne une composition pharmaceutique contenant un extrait d'écorce de Poria cocos comme principe efficace pour prévenir ou traiter des troubles neurodégénératifs, et une composition alimentaire pour prévenir ou améliorer des troubles neurodégénératifs. L'extrait d'écorce de Poria cocos contenu comme principe efficace dans la composition de la présente invention a une fonction de protection de neurones par génération de bêta-amyloïde, inhibition de phosphorylation de tau, et promotion de génération de NFG, et une fonction d'amélioration de la mémoire par protection de neurones et inhibition d'acétylcholinestérase, et peut donc être utilisé avantageusement dans une composition pharmaceutique pour prévenir ou traiter des troubles neurodégénératifs ou un aliment fonctionnel à cet effet. 본 발명의 복령피 (학명: Poria cocos) 추출물을 유효성분으로 함유하는 퇴행성 신경질환 예방 또는 치료용 약학적 조성물 및 퇴행성 신경질환 예방 또는 개선용 식품 조성물에 관한 것으로, 본 발명의 조성물에 포함되는 유효성분인 복령피 추출물은 베타아밀로이드 생성 및 타우 인산화 억제, NGF 생성 촉진작용을 통한 신경세포 보호작용, 신경세포 보호 및 아세틸콜린에스터라제 억제를 통한 기억력 개선작용을 가짐으로써, 퇴행성 신경질환 예방 또는 치료용 약학적 조성물, 또는 상기 목적의 건강식품으로 유용하게 사용될 수 있다.