18F LABELLED THIAZOLYLHYDRAZONE DERIVATIVES
The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these r...
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| Main Authors | , , , , |
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| Format | Patent |
| Language | English French |
| Published |
23.06.2016
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive compounds. The radioactive compounds of the invention can find use for in vivo imaging applications.
La présente invention concerne des composés de formule (I) dans laquelle R1 et R2 sont choisis, indépendamment l'un de l'autre, parmi le 19F et le 18F possédant une liaison sélective pour la MAO-B plutôt que pour la MAO-A. L'invention concerne également des versions radioactives de ces composés et des composés précurseurs utilisables en vue de la synthèse de ces composés radioactifs. Les composés radioactifs de cette invention peuvent être utilisés dans des applications d'imagerie in vivo. |
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| AbstractList | The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive compounds. The radioactive compounds of the invention can find use for in vivo imaging applications.
La présente invention concerne des composés de formule (I) dans laquelle R1 et R2 sont choisis, indépendamment l'un de l'autre, parmi le 19F et le 18F possédant une liaison sélective pour la MAO-B plutôt que pour la MAO-A. L'invention concerne également des versions radioactives de ces composés et des composés précurseurs utilisables en vue de la synthèse de ces composés radioactifs. Les composés radioactifs de cette invention peuvent être utilisés dans des applications d'imagerie in vivo. |
| Author | WYNN, DUNCAN, GEORGE RANGASWAMY, CHITRALEKHA JOSE, JINTO MORISSON-IVESON, VERONIQUE JACKSON, ALEXANDER |
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| DocumentTitleAlternate | DÉRIVÉS DE THIAZOLYLHYDRAZONE MARQUÉS AU 18F |
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| RelatedCompanies | GE HEALTHCARE LIMITED |
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| Snippet | The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as... |
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| SubjectTerms | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| Title | 18F LABELLED THIAZOLYLHYDRAZONE DERIVATIVES |
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