18F LABELLED THIAZOLYLHYDRAZONE DERIVATIVES

The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these r...

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Main Authors MORISSON-IVESON, VERONIQUE, WYNN, DUNCAN, GEORGE, RANGASWAMY, CHITRALEKHA, JOSE, JINTO, JACKSON, ALEXANDER
Format Patent
LanguageEnglish
French
Published 23.06.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to compounds of Formula (I) wherein R1 and R2 are independently selected from 19F and 18F having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive compounds. The radioactive compounds of the invention can find use for in vivo imaging applications. La présente invention concerne des composés de formule (I) dans laquelle R1 et R2 sont choisis, indépendamment l'un de l'autre, parmi le 19F et le 18F possédant une liaison sélective pour la MAO-B plutôt que pour la MAO-A. L'invention concerne également des versions radioactives de ces composés et des composés précurseurs utilisables en vue de la synthèse de ces composés radioactifs. Les composés radioactifs de cette invention peuvent être utilisés dans des applications d'imagerie in vivo.
Bibliography:Application Number: WO2015EP80609