COMPOUND HAVING GPR119 AGONISTIC ACTIVITY, METHOD FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AS EFFECTIVE COMPONENT

• Main Authors: SON, Moon Ho, YANG, Eun Kyoung, JUNG, Il Hoon, CHAE, Yu Na, KIM, Tae Hyoung, KIM, Yoon Jung, LEE, Hyo Ju, LEE, Jae Young, AHN, Chi Young, YANG, Jae Sung, KANG, So Mi, KIM, Mi Kyung, CHEONG, Ye Hwang, BAEK, Gye Rim, SHIN, Chang Yell
• Format: Patent
• Language: English; French
• Published: 16.03.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a novel compound having a GPR1 19 agonistic activity, a method for preparing the same, and a pharmaceutical composition including the same as an effective component. The present invention has an effective hypoglycemic action and an effect on pancreatic beta cells, and also improves lipid metabolism which is a chronic cardiovascular risk factor, thereby having a treatment and/or prevention effect of a metabolic disease such as diabetes. La présente invention concerne un nouveau composé ayant une activité agoniste GPR1 19, un procédé pour le préparer, et une composition pharmaceutique le comprenant comme constituant efficace. La présente invention présente une action hypoglycémiante efficace et un effet sur les cellules pancréatiques bêta, et améliore également le métabolisme des lipides qui est un facteur de risque cardiovasculaire chronique, ayant de là un effet de traitement et/ou de prévention d'une maladie métabolique telle que le diabète.