CARBIDOPA AND L-DOPA PRODRUGS AND THEIR USE TO TREAT PARKINSON'S DISEASE

• Main Authors: HENRY, RODGER F, KYM, PHILIP R, CHAN, VINCENT S, CARDINAL-DAVID, BENOIT, WANG, ZHI, STELLA, VALENTINO J, MILLER, CHRISTOPHER P, LOU, XIAOCHUN, HO, RAIMUNDO, MACKEY, SEAN E, KRABBE, SCOTT W, STAMBULI, JAMES, HUTERS, ALEXANDER D, MAYER, PETER T, DEMPAH, KASSIBLA E, VOIGHT, ERIC A, ENRIGHT, BRIAN P, HUANG, YE, KLIX, RUSSELL C, LAO, YANBIN, ZHANG, GEOFF G, MATULENKO, MARK A
• Format: Patent
• Language: English; French
• Published: 28.04.2016
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease. Cette divulgation concerne (a) des promédicaments de carbidopa, (b) des combinaisons et des compositions pharmaceutiques comprenant un promédicament de carbidopa et/ou un promédicament de L-dopa, et (c) des méthodes destinées à traiter la maladie de Parkinson et autres affections associées comprenant l'administration d'un promédicament de carbidopa et d'un promédicament de L-dopa à un sujet atteint de la maladie de Parkinson.