FUMARATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE

• Main Authors: SCHEUERMAN, RANDALL A, MANTHATI, SURESH K, RAILLARD, STEPHEN P
• Format: Patent
• Language: English; French
• Published: 21.04.2016
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Monomethyl and monoethyl fumarate prodrugs, pharmaceutical compositions comprising the monomethyl and monoethyl fumarate prodrugs, and methods of using monomethyl and monoethyl fumarate prodrugs and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis are disclosed. La présente invention concerne des promédicaments de fumarate de monométhyle et de monoéthyle, des compositions pharmaceutiques contenant ces promédicaments de fumarate de monométhyle et de monoéthyle et des promédicaments de fumarate de monoéthyle et des compositions pharmaceutiques pour traiter des troubles neurodégénératifs, inflammatoires et auto-immuns, tels que la sclérose en plaques, le psoriasis, le syndrome du côlon irritable, la rectocolite hémorragique, l'arthrite, la bronchopneumopathie obstructive chronique, l'asthme, la maladie de Parkinson, la maladie de Huntington et la sclérose latérale amyotrophique.