SUBSTITUTED AMINOPURINE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are Aminopurine Compounds having the following structures wherein R1, R2, and R3 are as defined herein, composition comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma. Provided herein are compounds having...

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Main Authors JEFFY, BRANDON, HUANG, DEHUA, ZHAO, JINGJING, MOGHADDAM, MEHRAN, LEISTEN, JIM, TORRES, EDUARDO, RAHEJA, RAJ, K, TRAN, TAM, MINH, ALEXANDER, MATTHEW, SLOSS, MARIANNE, SCHWARZ, KIMBERLY, HANSEN, JOSHUA, BAHMANYAR, SOGOLE, HUBBARD, ROBERT, RAYMON, HEATHER, XU, SHUICHAN, BOYLAN, JOHN, FREDRERICK
Format Patent
LanguageEnglish
French
Published 14.04.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Provided herein are Aminopurine Compounds having the following structures wherein R1, R2, and R3 are as defined herein, composition comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma. Provided herein are compounds having the following formula (I) and pharmaceutically acceptable salts, tautomers, isotopologues, and stereoisomers thereof, wherein R1, R2 and R3 are as defined herein. La présente invention concerne des composés aminopurine ayant les structures suivantes, R1, R2, et R3 étant tels que définis dans la description, la composition comprenant une quantité efficace d'un composé aminopurine, et des procédés de traitement ou de prévention d'un cancer, par exemple, d'un mélanome. La présente invention décrit des composés ayant la formule suivante (I) et leurs sels, tautomères, isotopologues, et stéréo-isomères pharmaceutiquement acceptables, R1, R2 et R3 étant tels que définis dans la description.
Bibliography:Application Number: WO2015US53941