METHYL-AND TRIFLUOROMETHYL-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF

• Main Authors: FLICK, ANDREW CHRISTOPHER, JONES, PETER, XING, LI, TRZUPEK, JOHN DAVID, WENNERSTÅL, GÖRAN MATTIAS, ZHANG, LIYING, ZAMARATSKI, EDOUARD, VAZQUEZ, MICHAEL L, KAILA, NEELU, MENTE, SCOT RICHARD, SCHNUTE, MARK EDWARD
• Format: Patent
• Language: English; French
• Published: 31.03.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides methyl-and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmac...