METHYL-AND TRIFLUOROMETHYL-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF

• Main Authors: FLICK, ANDREW CHRISTOPHER, JONES, PETER, XING, LI, TRZUPEK, JOHN DAVID, WENNERSTÅL, GÖRAN MATTIAS, ZHANG, LIYING, ZAMARATSKI, EDOUARD, VAZQUEZ, MICHAEL L, KAILA, NEELU, MENTE, SCOT RICHARD, SCHNUTE, MARK EDWARD
• Format: Patent
• Language: English; French
• Published: 31.03.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides methyl-and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating RORγ activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof. Cette invention concerne des pyrrolopyridines substitués par un méthyle et trifluorométhyle, des compositions pharmaceutiques les contenant, des procédés d'inhibition de l'activité de RORγ et/ou de réduction de la quantité d'IL-17 chez un sujet, ainsi que des méthodes de traitement de différents troubles médicaux à l'aide desdites pyrrolopyridines et desdites compositions pharmaceutiques les contenant.