PHARMACEUTICAL COMPOSITION FOR TREATING AND PREVENTING DEGENERATIVE NEUROLOGICAL DISORDERS, CONTAINING, AS ACTIVE INGREDIENT, MIXTURE EXTRACT OF MOUTAN ROOT BARK, ANGELICA DAHURICA ROOT AND BUPLEURUM ROOT OR FRACTION THEREOF
The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of moutan root bark (Moutan Radicis Cortex), Angelica dahurica...
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Main Authors | , , , , , , , , , , , , |
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Format | Patent |
Language | English French Korean |
Published |
24.03.2016
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of moutan root bark (Moutan Radicis Cortex), Angelica dahurica root (Angelicae Dahuricae Radix) and bupleurum root (Bupleuri Radix), or a fraction thereof. Specifically, the mixture extract of the present invention simultaneously exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the mixture extract significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the mixture extract of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.
La présente invention concerne une composition pharmaceutique destinée à traiter et à prévenir des troubles neurologiques dégénératifs contenant, comme principe actif, un extrait de mélange de deux types ou plus choisis dans le groupe constitué par de l'écorce de racine de pivoine arborescente (Moutan Radicis Cortex), de la racine d'Angelica dahurica (Angelicae Dahuricae Radix) et de la racine de bupleurum (Bupleuri Radix), ou une fraction de celui-ci. Plus précisément, l'extrait de mélange de la présente invention présente simultanément un effet de récupération sur les dommages de la fonction mitochondriale, un effet de soulagement sur le stress du réticulum endoplasmique et un effet inhibiteur sur la réponse inflammatoire, qui sont remarquablement améliorés par rapport à ceux présentés dans un extrait simple in vitro et l'extrait de mélange présente de manière significative un effet d'amélioration sur la coordination motrice et un effet protecteur sur les neurones dopaminergiques dans un modèle animal de la maladie de Parkinson et, ainsi, l'extrait de mélange de la présente invention ou une fraction de celui-ci peut être utile en tant que principe actif d'une composition pharmaceutique destinée à traiter et à prévenir des troubles neurologiques dégénératifs.
. 본 발명은 목단피 (Moutan Root Bark, Moutan Radici s Cortex), 백지 (Angel ica Dahur ica Root, Angel icae Dahur i cae Radix) 및 시호 (Bupleurum Root, Bupleur i Radix)로 구성된 군으로부터 선택된 2 종 이상의 흔합 추출물 또는 이의 분획물을 유효성분으로 함유하는, 신경 퇴행성 질환의 치료 및 예방용 약학적 조성 물에 관한 것으로, 구체적으로 본 발명의 혼합 추출물은 사험관 내 ( in vi tro)에서 단독 추출물에서 나타나는 것보다 현저하게 상승한 미토콘드리아 기능 손상 회복 효과, 소포체 스트레스 완화 효과, 염증반웅 억제 효과를 동시에 나타내며, 상기 흔합 추출물은 파킨슨병 동물 모델에서 운동 협웅 (motor coordinat ion) 개선 효과 및 도파민 신경세포 보호 효과를 유의적으로 나타내므로, 본 발명의 흔합 추출물 또는 이의 분획물은 신경 퇴행성 질환 치료 및 예방용 약학적 조성물의 유효성분으 로서 유용하게 사용될 수 있다. |
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Bibliography: | Application Number: WO2015KR09717 |