DIAMIDE MACROCYCLES THAT ARE FXIA INHIBITORS

The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention als...

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Bibliographic Details
Main Authors EWING, WILLIAM R, SHI, JUN, NIELSEN, LAURA, QUAN, MIMI L, HU, ZILUN
Format Patent
LanguageEnglish
French
Published 10.03.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same. La présente invention concerne des composés de formule (I) ou des stéréo-isomères, des tautomères ou des sels de qualité pharmaceutique de ceux-ci. Dans ladite formule, toutes les variables ont la signification indiquée dans la description. Ces composés sont des inhibiteurs sélectifs du facteur XIa ou des inhibiteurs doubles du fXIa et de la kallikréine du plasma. Cette invention porte également sur des compositions pharmaceutiques comprenant ces composés, et sur des méthodes de traitement de troubles thrombo-emboliques et/ou inflammatoires dans lesquelles on utilise lesdits composés.
Bibliography:Application Number: WO2015US48212