COFORMER SALTS OF (2S,3S)-METHYL 7-FLUORO-2-(4-FLUOROPHENYL)-3-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-4-OXO-1,2,3,4-TETRAHYDROQUINOLINE-5-CARBOXYLATE AND METHODS OF PREPARING THEM

Described herein are coformer salts of (2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3- ( 1-methyl- 1H- 1,2,4-triazol-5-yl)-4-oxo-l,2,3,4-tetrahydroquinoline-5-carboxylate optionally as a solvate and additionally optionally as a hydrate, including crystalline forms, and methods of preparing the (2S,3S)...

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Main Authors HERZ, CHRISTIAN, KLAUS, BONNAUD, THIERRY, LAMBERT, OLIVIER, JAGUSCH, CARSTEN, HENDERSON, MARK, BAUER, NICO, CAMPBELL, COLM
Format Patent
LanguageEnglish
French
Published 04.02.2016
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Described herein are coformer salts of (2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3- ( 1-methyl- 1H- 1,2,4-triazol-5-yl)-4-oxo-l,2,3,4-tetrahydroquinoline-5-carboxylate optionally as a solvate and additionally optionally as a hydrate, including crystalline forms, and methods of preparing the (2S,3S)-methyl 7-fluoro-2-(4-fluorophenyl)-3-( 1-methyl- 1H-1, 2,4-triazol-5- yl)-4-oxo-l,2,3,4-tetrahydroquinoline-5-carboxylate optionally as a coformer salts. L'invention concerne des sels conformères de 7-fluoro-2-(4-fluorophényl)-3- (1-méthyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tétrahydroquinoléine-5-carboxylate de (2S,3S)-méthyle, éventuellement sous forme de solvate et en outre éventuellement sous forme d'hydrate, y compris les formes cristallines, et des procédés de préparation de 7-fluoro-2-(4-fluorophényl)-3-(1-méthyl-1H-1,2,4-triazol-5-yl)-4-oxo-1,2,3,4-tétrahydroquinoléine-5-carboxylate de (2S,3S)-méthyle, éventuellement sous forme de sels conformères.
Bibliography:Application Number: WO2015US42867