INHIBITORS OF DEUBIQUITINATING PROTEASES

Disclosed are small molecule inhibitors of deubiquitinating enzymes (DUBs), and methods of using them. Certain compounds are selective for particular ubiquitin-specific proteases (USPs). L'invention concerne des inhibiteurs à petites molécules d'enzymes de désubiquitination (DUB) et leurs...

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Main Authors HEDSTROM, LIZBETH, K, LAWSON, ANN, PARRINELLO, LONG, MARCUS, J
Format Patent
LanguageEnglish
French
Published 28.01.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Disclosed are small molecule inhibitors of deubiquitinating enzymes (DUBs), and methods of using them. Certain compounds are selective for particular ubiquitin-specific proteases (USPs). L'invention concerne des inhibiteurs à petites molécules d'enzymes de désubiquitination (DUB) et leurs méthodes d'utilisation. Certains composés sont sélectifs de protéases spécifiques de l'ubiquitine (USP) particulières.
Bibliography:Application Number: WO2015US41319