ISOQUINOLINONE DERIVATIVES AS PARP INHIBITORS

• Main Authors: KUKREJA, GAGAN, KURHADE, SANJAY, PRALHAD, GUPTA, NISHANT, RAMNIWASJI, PALLE, VENKATA, P, KAMBOJ, RAJENDER, KUMAR, SINHA, NEELIMA, TILEKAR, AJAY, RAMCHANDRA, IRLAPATI, NAGESWARA, RAO, JANA, GOURHARI, KARCHE, NAVNATH, POPAT
• Format: Patent
• Language: English; French
• Published: 28.01.2016
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed are compounds of formula (I), their tautomeric forms, stereoisomers, and pharmaceutically acceptable salts thereof, wherein R1-R6, p and q are as defined in the specification, pharmaceutical compositions including a compound, tautomer, stereoisomer, or salt thereof, and methods of treating or preventing diseases or disorders, for example, cancer, that are amenable to treatment or prevention by inhibiting the PARP enzyme of a subject. L'invention concerne des composés de formule (I), leurs formes tautomères, stéréoisomères, et des sels pharmaceutiquement acceptables de ceux-ci, dans laquelle R1-R6, p et q ont la signification indiquée dans la description, des compositions pharmaceutiques comprenant un composé, un tautomère, un stéréoisomère, ou un sel de celui-ci, et des procédés de traitement ou de prévention de maladies ou de troubles, par exemple, le cancer, dont le traitement ou la prévention peut être assuré par inhibition de l'enzyme PARP d'un patient.