ANTI-FOLATE RECEPTOR APLHA (FRA) ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THEREOF

The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers. La présente invention concerne des conjugués médicament-anticorps anti-réc...

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Main Authors LEE, SHU-HUA, HU, LI-AN, TSAI, YU-YING, CHIANG, FENG-LIN, LIN, SHIH-YAO, LIN, RONG-HWA, HSIEH, YUI, HUANG, CHIUN
Format Patent
LanguageEnglish
French
Published 23.12.2015
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers. La présente invention concerne des conjugués médicament-anticorps anti-récepteur alpha du folate (FRA) comprenant une séquence de liaison auto-immolable hydrophile. La présente invention concerne en outre des compositions et des procédés pour le traitement de cancers.
Bibliography:Application Number: WO2015US36824