SYMMETRICAL POLAR INHIBITORS OF CHOLINE KINASE WITH ANTI-TUMOUR ACTIVITY
The invention relates to symmetrical polar compounds of bispyridinium, bisquinuclidinium and bisquinolinium with a linker derived from 1,2-bis(p-tolyloxy)ethane, which are inhibitors of choline kinase. The invention also relates to the synthesis thereof and to the use of same as anti-tumour medicame...
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Main Authors | , , , , , , , , , |
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Format | Patent |
Language | English French Spanish |
Published |
10.12.2015
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Subjects | |
Online Access | Get full text |
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Summary: | The invention relates to symmetrical polar compounds of bispyridinium, bisquinuclidinium and bisquinolinium with a linker derived from 1,2-bis(p-tolyloxy)ethane, which are inhibitors of choline kinase. The invention also relates to the synthesis thereof and to the use of same as anti-tumour medicaments.
La presente invención se refiere a compuestos polares simétricos de bispiridinio, bisquinuclidinio y bisquinolinio con un linker derivado del1,2-bis(p-toliloxi)etano inhibidores de colina cinasa, su síntesis y su uso como medicamento antitumoral.
La présente invention concerne des composés polaires symétriques de bipyridine, de bisquinuclidine et de bisquinoline qui comprennent un coupleur dérivé du 1,2-bis(p-tolyloxy)éthane, qui sont des inhibiteurs de choline kinase , leur synthèse et leur utilisation comme médicament antitumoral. |
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Bibliography: | Application Number: WO2015ES70437 |