SYMMETRICAL POLAR INHIBITORS OF CHOLINE KINASE WITH ANTI-TUMOUR ACTIVITY

The invention relates to symmetrical polar compounds of bispyridinium, bisquinuclidinium and bisquinolinium with a linker derived from 1,2-bis(p-tolyloxy)ethane, which are inhibitors of choline kinase. The invention also relates to the synthesis thereof and to the use of same as anti-tumour medicame...

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Main Authors LÓPEZ CARA, LUISA CARLOTA, SCHIAFFINO ORTEGA, SANTIAGO, MARCO DE LA CALLE, CARMEN, CARRASCO JIMÉNEZ, MARÍA PAZ, BASSO, GIUSSEPE, BORTOLOZZI, ROBERTA, ESPINOSA UBEDA, ANTONIO, RÍOS MARCO, PABLO, VIOLA, GIAMPIETRO, ENTRENA GUADIX, ANTONIO JOSÉ
Format Patent
LanguageEnglish
French
Spanish
Published 10.12.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The invention relates to symmetrical polar compounds of bispyridinium, bisquinuclidinium and bisquinolinium with a linker derived from 1,2-bis(p-tolyloxy)ethane, which are inhibitors of choline kinase. The invention also relates to the synthesis thereof and to the use of same as anti-tumour medicaments. La presente invención se refiere a compuestos polares simétricos de bispiridinio, bisquinuclidinio y bisquinolinio con un linker derivado del1,2-bis(p-toliloxi)etano inhibidores de colina cinasa, su síntesis y su uso como medicamento antitumoral. La présente invention concerne des composés polaires symétriques de bipyridine, de bisquinuclidine et de bisquinoline qui comprennent un coupleur dérivé du 1,2-bis(p-tolyloxy)éthane, qui sont des inhibiteurs de choline kinase , leur synthèse et leur utilisation comme médicament antitumoral.
Bibliography:Application Number: WO2015ES70437