ADDITION SALTS OF (S)-2-(1-(6-AMINO-5-CYANOPYRIMIDIN-4-YLAMINO)ETHYL)-4-OXO-3-PHENYL-3,4-DIHYDROPYRROLO[1,2-F][1,2,4]TRIAZINE-5-CARBONITRILE

The present invention is directed to novel pharmaceutically acceptable, addition salts of (S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4- dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile with sulfonic acid derivatives, in particular with methanesulfonic acid, naphthalene-2...

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Main Authors CARRERA CARRERA, FRANCESC, VIDAL JUAN, BERNAT, PEREZ GARCIA, JUAN BAUTISTA, SERRA COMA, MARIA CARME, SANCHEZ IZQUIERDO, FRANCISCO
Format Patent
LanguageEnglish
French
Published 03.12.2015
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention is directed to novel pharmaceutically acceptable, addition salts of (S)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4- dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile with sulfonic acid derivatives, in particular with methanesulfonic acid, naphthalene-2-sulfonic acid and para-toluenesulfonic acid, and pharmaceutically acceptable solvates thereof, and their use as Phosphoinositide 3-Kinase (PI3K) inhibitors. Cette invention concerne de nouveaux sels d'addition pharmaceutiquement acceptables de (S)-2-(1-(6-amino-5-cyano-pyrimidin-4-ylamino)éthyl)-4-oxo-3-phényl-3,4-dihydropyrrolo[1,2-f] [1,2,4] triazine-5-carbonitrile avec des dérivés d'acide sulfonique, en particulier avec de l'acide méthanesulfonique, de l'acide naphtalène-2-sulfonique et de l'acide para-toluènesulfonique, leurs solvates pharmaceutiquement acceptables, et leur utilisation à titre d'inhibiteurs de phosphoinositide 3-Kinase (PI3K).
Bibliography:Application Number: WO2015EP61307