ION CHANNEL MODULATORS AND USES THEREOF

The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies fo...

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Main Authors JONES, CLARE, LINLEY, JOHN, SNIJDER, HARM JAN, BUTTON, JAMES, GROVES, MARIA, SHIBATA, YOKO, WILLIAMS, WENDY A, SRIDHARAN, SUDHARSAN, HUANG, LING, DOBSON, CLAIRE
Format Patent
LanguageEnglish
French
Published 05.11.2015
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The invention provides antibodies that specifically bind a P2X4 polypeptide and modulate P2X4 channel activity, recombinant P2X4 polypeptides and methods for generating such polypeptides, as well as compositions and methods for generating anti-P2X4 antibodies, and methods of using P2X4 antibodies for the treatment of neuropathic pain and other indications. L'invention concerne des anticorps qui se lient spécifiquement à un polypeptide P2X4 et modulent l'activité des canaux P2X4, des polypeptides recombinants P2X4 et des procédés permettant de produire ces polypeptides ainsi que des compositions et des procédés pour générer des anticorps anti-P2X4 et des procédés d'utilisation des anticorps P2X4 en cas de douleur neuropathique ou d'autres indications.
Bibliography:Application Number: WO2015EP59633