ORAL SOLUTION COMPRISING ATOMOXETINE HYDROCHLORIDE

Oral aqueous solutions comprising atomoxetine hydrochloride as active ingredient and a liquid carrier comprising xylitol, maltitol and a sweetener which is selected from the group consisting of sucralose, saccharin, sodium or calcium saccharin, stevioside and rebaudioside. The pH of the solution is...

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Main Authors STAPPA, ARGYRO, KARATZAS, ANGELOS, APOSTOLOU, ΚONSTANTINOS, KOTSIANIS, ILIAS
Format Patent
LanguageEnglish
French
Published 01.10.2015
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Oral aqueous solutions comprising atomoxetine hydrochloride as active ingredient and a liquid carrier comprising xylitol, maltitol and a sweetener which is selected from the group consisting of sucralose, saccharin, sodium or calcium saccharin, stevioside and rebaudioside. The pH of the solution is adjusted to the range of 3.5 to 4.5. The solutions of the present invention are palatable even in the absence of further polyhydric or sugar alcohols, in addition to xylitol and maltitol. La présente invention concerne des solutions aqueuses orales contenant du chlorhydrate d'atomoxétine en tant que principe actif et un excipient liquide comprenant du xylitol, du maltitol et un édulcorant qui est choisi dans le groupe constitué du sucralose, de la saccharine, de la saccharine sodique ou calcique, du stévioside et du rébaudioside. Le pH de la solution est réglé sur 3,5 à 4,5. Les solutions de la présente invention sont de goût agréable, même en l'absence d'autres alcools polyhydriques ou d'autres alcools de sucre en plus du xylitol et du maltitol.
Bibliography:Application Number: WO2014EP59020