MEMBRANE FOR BLOOD PURIFICATION

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (...

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Bibliographic Details
Main Authors BEHR, HEINRICH, LOERCHER, JOACHIM, VOIGT, MANUEL, HERBST, PHILIPP, KRAUSE, BERND, ZWEIGART, CARINA, HORNUNG, MARKUS, STORR, MARKUS, BUCK, REINHOLD, WOCHNER, ARND, BOSCHETTI-DE-FIERRO, ADRIANA, BECK, WERNER
Format Patent
LanguageEnglish
French
Published 13.08.2015
Subjects
DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
TRANSPORTING
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Summary:The present disclosure relates to semipermeable membranes which are suitable for blood purification, e.g. by hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (MWRO) of between 9.0 kD and 14.5 kD and a molecular weight cut-off (MWCO) of between 55 kD and 130 kD as determined by dextran sieving curves and can be prepared by industrially feasible processes excluding a treatment with salt before drying. The invention therefore also relates to a process for the production of the membranes and to their use in medical applications. La présente invention concerne des membranes semi-perméables qui sont appropriées pour la purification du sang, par exemple par hémodialyse, qui ont une capacité accrue à éliminer des molécules plus grosses tout en retenant simultanément l'albumine efficacement. Les membranes sont caractérisées par un début de rétention moléculaire (MWRO) compris entre 9,0 kD et 14,5 kD et un seuil de coupure de poids moléculaire (MWCO) compris entre 55 kD et 130 kD tel que déterminé par des courbes de filtration de dextrane et peuvent être préparées par des processus industriellement faisables en excluant un traitement avec du sel avant le séchage. L'invention concerne en outre un procédé de production des membranes et leur utilisation dans des applications médicales.
Bibliography:Application Number: WO2015EP52364